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Boosting and Modulating the Immune Response in Our Animals

Dr. Will Falconer, DVM - "Most of the chronic diseases we commonly see in animals have an immune basis, e.g. diabetes, allergies, asthma, thyroid disease, inflammatory bowel diseases, repeated ear infections, cancer, etc. While they can be cured through the careful use of homeopathy, the road to cure can be a long one -- often years if the animal has had years of disease. Unique immune molecules can significantly shorten the course, by giving a much needed balancing effect to the immune system. If the immune system is overactive as in allergies, ear infections, asthma, diabetes, or hypothyroidism, this unique immune molecule can balance this over activity so the system is not attacking its own organs, overreacting to things that shouldn't be perceived as a threat. If, conversely, the immune system is under-active as in mange, parasites, viral infections, or cancer, this immune molecule can clearly stimulate it to better meet the challenges it needs to be alert to."

Optimizing Our Animal's Immune Response

Improving immune response in our domesticated animals Dr. Marlice Vonck, DVM "A cat with Leukemia, an oral tumor, and posterior paralysis due to a spinal tumor was very ill and emaciated. One month after starting her on an immune boosting supplement there was some regression of the oral tumor, restored appetite with some weight gain, and increased sociability. Five months later, this cat continues to improve - she regained her normal weight, her oral tumor has regressed 80%, and she has regained the use of her hind legs and tail."

Simply stated, Immune Modulator Nutritionals are tiny molecules that are able to convey immunity information from one entity to another to educate naive cells about a present or potential danger along with a plan for action. Although the mostly notable function of these smart molecules is to speed up the recognition phase of an infection making the duration of an illness much shorter, these molecules also have the ability to suppress an over active immune system. All said, these nutritionals have the ability to balance out the function of our immune system and that of our animals, whether it needs to increase in function or be reduced in the case of auto-immune disorders.

For more information about Boosting and Modulating the Immune Response in large and small animals Contact Shirley

Dr. Will Falconer DVM - "For decades, the approach to maintaining healthy animals was to wait for signs and symptoms of disease to occur and to counter the challenge with an array of drugs which were toxic for the disease causing agent. This approach is now being questioned as the armada of drugs is diminishing due to multiple drug resistant pathogens. Compounding this alarming trend is the current approach to health maintenance which assumes that "all is well" until actual disease processes begin.

By this time, the disease is established, sometimes irreversibly, and the damage has occurred. So the questions arises...What if a new paradigm existed? Could it be possible to optimize the immune status of animals so that (1) disease is much less likely to occur and (2) if disease does occur, it's severity and duration is minimized? The answer is YES and this paradigm shift is being engineered by small, naturally occurring protein-like immune messenger molecules."

Vaccinations may even contribute to premature death in animals whose immune systems were already compromised, some veterinarians believe. "I had two situations where we had spent a long time building up two older, severely immune system compromised dogs, and then their owners had them vaccinated for just about everything known to man," recalled Dr. Carvel Tiekert, executive director and founder of the American Holistic Veterinary Medical Association headquartered in Bel Air, Maryland.

"Both of those dogs died within about a month of vaccination. Can we prove a cause and effect? No. Do I think there was a cause and effect? Yes."

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natural immune enhancing supplement generates a highly 
concentrated immune messaging system in petsVeterinarians Addressing Our Pet's Immune System

Dr. Marlice Vonck, DVM - " These intelligent immune messenger molecules is truly the missing link in the nutritional approach to preventive practice for all pets. It is a powerful immune system activator that has the ability to boost the immune system in an entirely different way and has been a remarkable addition to my veterinary practice. It is an amazing immune booster that provides support for so many conditions that animals have.""

Question to Dr. Falconer: does vaccination (or over-vaccination) causes overactive immune reaction (autoimmune disorder) or does it cause suppression of the immune system?

Will Falconer Dr. Will Falconer D.V.M: "The answer is YES. Probably both. Vaccination 'confuses' the immune system, as I point out in my heart worm eBook. So, it could go either way, or alternate over time between the two. Immune Modulator supplements are natural nutritionals that help support the animal's immune system. A healthy immune system is capable of helping the body heal itself. These unique immune molecules should be given before and immediately after vaccination for at least a few weeks to help ameliorate the confusion (when someone is faced with a mandatory vaccination, or has decided they want to give one). By giving the immune system an immune support it should be able to better sort through the confusion, though I'm not sure that's measurable."

"A four month old kitten had a severe skin condition that was diagnosed as ringworm. After four months of conventional therapy, the resistant ringworm infection was not resolved. We put the kitten on the immune boosting supplement and within 5 days there were no apparent ringworm lesions remaining. Within a few weeks all the hair had grown back - and the now 9 month old cat has a beautiful, glossy coat. The ringworm lesions have not returned."

"Two cats, both about 8 years old, had severe diabetes. It was impossible to get the insulin requirements adjusted. They had lost weight to a point that they were skin and bones. Both cats had no quality of life left. After one week of being on the immune boosting supplement, we were able to get their insulin requirements adjusted. It is now six months later and they have both regained their weight, and have a great quality of life and health."

Deadly, Contagious Dog Flu Virus

Dr. Cynda Crawford, an immunologist at the University of Florida's College of Veterinary Medicine who is studying the virus, said that it spread most easily where dogs were housed together but that it could also be passed on the street, in dog runs or even by a human transferring it from one dog to another. Kennel workers have carried the virus home with them.

Have a question or need assistance? Email Shirley or call 323-522-4521

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Doctor Saved His Dogs From Distemper

Dr. Baruch Rosen, M.D.

 "As a physician of nearly thirty years, I was well aware that no antibiotic would protect against the ravages of viral disease, particularly canine distemper which shows similarities to HIV. My seven month old white haired Shepard was adopted from a local shelter and was initially joyful and healthy. Within three weeks he developed coarse bronchitis with heavy mucus drainage of the nose and eyes. Our well intentioned vet believed the problem to be kennel cough and started antibiotics. Over the next ten days Romeo failed to improve, but instead experienced seven hard and long grand mall seizures in one weekend, a partial paralysis of the hind quarters which made him fall flat when attempting to walk and a "spaced-out gaze" of non-recognition. Blood studies confirmed distemper and showed a white cell count (lymphocytes) of only 264 slightly more than ten percent of normal. Our vet a second out-of-state consulting vet, an expert in distemper were very sympathetic and advised me to prepare myself to euthanize Romeo."

"The heartache was compounded when Chico, my thirteen month old Chihuahua developed similar symptoms of hard coughing and heavy mucus drainage from the eyes. Reviewing his shot record, I learned he was mistakenly given only one distemper immunization, leaving him inadequately protected; and by licking Romeo's mucus and drinking from his water dish had contracted the infection."

"Knowing little to nothing about canine distemper, I turned to the Internet and luckily stumbled on to a unique immune support supplement, a preparation which enhances and stimulates the body's own immune system to fight against all pathogens, viral or otherwise. My thirty years in medicine told me this was the only solution. I hurriedly became a distributor to get the product and started Chico and Romeo on one cap daily encased in one teaspoonful of raw hamburger. Over the next two weeks all cough and mucus drainage ceased. Romeo's follow-up blood count had risen to normal range at 2217 and he surprised the whole family by jumping a five foot wall. He romps and plays all day long with Chico, now responds normally to his name and appears to be his old joyful self again."

"Having witnessed the recoveries of Chico and Romeo, and after further study, all family members are taking a unique immune support supplement, one cap daily; our insurance policy to protect against a faltering immune system, the inevitable consequence of aging and exposure to environmental pollution and toxins. As for my distributorship status, I fully intend to spread the word to all my colleagues and good friends."  Dr. Baruch Rosen, M.D.

Contact Shirley for information

The Immune Response in Horses and Livestock

Dr. Molly Metz, DVM, Lexington, Kentucky

  • A 3-yr-old warm blood with history of chronic cough and nasal discharge was unresponsive to antibiotics. Within two weeks of being on this immune restore supplement, both the nasal discharge and cough went away. This colt is being maintained on a maintenance dose of this product.
  • A 19-yr-old late gestation mare had stringhalt, ataxia, and moderate ear droop. I began the mare on on this supplement to improve its immune function prior to foaling. After 30 days of being on this natural immune enhancing substance, this mare had no evidence of stringhalt or ataxia, and only a mild ear droop. This is the first time in her life she was able to pull her ear forward in a normal position. She also is cushionoid and suffered miserably in last summer's heat, being unable to sweat. This spring, when temperatures reached 80 degrees, she was sweating in the field.
  • I had a 2I had a 2-year-old thoroughbred filly with a history of multiple bone pain and suspected neurological condition. This filly was diagnosed with physitis in multiple bones (via bone scan) and as a wobbler on radiographs. I placed her on the natural immune enhancing supplement to see if she could be improved enough to go into training. The farm has begun breaking her and her movement has improved by approximately 80%. I am waiting to hear if the farm feels she's good enough to go to the track.

Gelding Recovers from Severe Dermatitis

9-yr- old Friesian gelding developed severe dermatitis in January 2001. The gelding went from being a beautiful black horse with full mane and tail to having huge bald spots all over his body. He lost his entire mane and most of his tail. Our vet, Mike Marrinan, visited twice weekly to do Betadine scrubs and he put Prince on antibiotics. Dr. Marrinan took biopsies and sent them to two universities. He spoke with numerous specialists, but none could tell us what was wrong. Our last resort was to put him on steroids. His lesions gradually cleared and his hair started to grow back. By the summer of 2001 we were again riding Prince; however, it became evident that the side effects of steroids were negatively affecting him. He was not holding his weight and became spooky and unpredictable.

In the fall of 2001 Dr. Marrinan decided to gradually take him off steroids. Two weeks after he concluded steroid use, a fresh lesion appeared on his face. His immune system was severely compromised, White blood count was 3000 (normal is 15,000). He developed a chronic eye infection and then really got sick. His fever spiked, he became depressed, and stopped eating and drinking. Dr. Marrinan tried Sulfa drugs and IV's for three days. He put him on Naxel; nothing worked. Prince had given up; we were sure he was dying. I came across an article in The Horse regarding the immune system. It spoke of a unique immune modulating supplement. Upon finding an ad for the product I called Dr. Marrinan and asked him about it. He said, "try it, nothing else is working."

I got a two week allotment of this supplement. We didn't want to commit to more; we had already spent thousands of dollars on Prince. There comes a time when you have to be realistic and say enough is enough. After ten days on this immune support product, brightness came back into Prince's eyes which we hadn't seen in months. His appetite increased and he was drinking water again. I called my friend and ordered special formula for horse. After two weeks his coat started getting glossy again and his appetite returned. Two and a half months later he is fully recovered! He is playing in the field again; his mane and tail are growing back; his dermatitis is gone; and his eyes are bright and clear! It is so awesome to see Prince running across the field kicking up his heels with his pasture pals! I truly believe that this immune supplement has saved Prince's life.

The following are testimonies from Lisa Hampton, Trainer, in Montana:
  • I had a 9-yr-old quarter horse mare named Annie. She started colicking on a Sunday and was suffering from a severe compaction. It became obvious by the second day that we were not dealing with a normal colic. She was showing some neurological signs and her temperature would bounce from 96 to 102. Our vet, Mike Marrinan, came out every day to tube her with mineral oil and give her IVs. Her blood test showed her liver and kidney functions were off, as was her blood count. On day three her gums were bright fuschia, her pulse was 78 and her capillary refill time was 4 seconds; we thought we were going to lose her. Day four she started passing stools. Day five she got severe diarrhea. The diarrhea and depression lasted for five days. She lost about 200 pounds and her coat turned coarse and dull. She had patches of skin that were sloughing and her extremities were swelling, including her face. All of these were signs that she was fighting something toxic. I started her on a unique horse immune booster formula. After four days of being on that she started eating aggressively, jigged to the pasture, and her eyes were bright and clear. She has put most of her weight back on. Annie was 30 days pregnant when she colicked, you can't imagine our joy when we did a 65-day ultrasound and saw her fetus doing back flips. We continue to feed Annie this product throughout her pregnancy. I am convinced that this immune support product is helping her body fight and the probiotics are aiding in the digestion and healing her gut.
  • I had a six-week old quarter horse foal. Monday morning I entered the stall and the foal was lying down looking depressed. The mare has a swollen udder; obviously the foal was not eating. The foal's temperature was 102.5. Whenever a foal gets sick it makes you feel so helpless, as they can dehydrate quickly and really go downhill fast. I immediately made a paste with this immune booster powder, sulfa tabs, and electrolytes. I gave the paste to the foal both morning and night, and milked out the mare to keep her comfortable. On day two, the foal had severe diarrhea and was still not eating, and was still depressed. I continued giving the horse formula and antibiotics. Day four I had to chase the little guy down to paste him. His temperature was 99 and he was nursing again; he had no diarrhea. On day five you would have never known the foal had been sick. He was running and playing and, remarkably, had lost no weight. I continued to paste him for seven days. I have never had a foal recover this quickly from fever and diarrhea...and no vet bills.

Have a question or need assistance? Email Shirley or call 323-522-4521

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Equine Protozoa Myeloencephalitis EPM

A new paradigm for the treatment and prevention of infections and stress induced immune suppression
R.H. Bennett Ph.D.

Introduction: EPM and other chronic diseases of horses and other mammals have a pattern of wide geographic exposure to significant proportions of an animal population, yet a small subset of the exposed progress to clinical disease. This proportionality suggests that other modifying factors have a major role in disease expression. The case in point here is EPM. There is wide environmental exposure, as evidenced by seroconversion, yet only 1 to 2 percent become clinically affected. The phenotype of the individual most likely is a major determinant.

Horses that are highly genetically selected for performance or type traits most likely lose genetic potentials for robust immune responsiveness, as is the case for most species. Those individuals that experience the stressors of transportation and training may then present a phenotype that is immunologically stress sensitive. This subset is apparently small, but may be the group most likely to succumb to immune challenges like that of EPM. The question then is how can the immune abilities of the animal be supported to restore these phenotypic challenges?

Neurologic disease in horses caused by Sarcocystis neurona is difficult to diagnose, treat, or prevent, due to the lack of knowledge about the pathogenesis of the disease. This in turn is confounded by the lack of a reliable equine model of equine protozoal myeloencephalitis (EPM). Epidemiologic studies have implicated stress as a risk factor for this disease, thus, the role of transport stress was evaluated for incorporation into an equine model for EPM. Sporocysts from feral opossums were bioassayed in interferon-gamma gene knockout (KO) mice to determine minimum number of viable S. neurona sporocysts in the inoculum. A minimum of 80,000 viable S. neurona sporocysts were fed to each of the nine horses. A total of 12 S. neurona antibody negative horses were divided into four groups (1-4). Three horses (group 1) were fed sporocysts on the day of arrival at the study site, three horses were fed sporocysts 14 days after acclimatization (group 2), three horses were given sporocysts and dexamethasone 14 days after acclimatization (group 3) and three horses were controls (group 4).

All horses fed sporocysts in the study developed antibodies to S. neurona in serum and cerebrospinal fluid (CSF) and developed clinical signs of neurologic disease. The most severe clinical signs were in horses in group 1 subjected to transport stress. The least severe neurologic signs were in horses treated with dexamethasone (group 3). Clinical signs improved in four horses from two treatment groups by the time of euthanasia (group 1, day 44; group 3, day 47). Post-mortem examinations, and tissues that were collected for light microscopy, immunohistochemistry, tissue cultures, and bioassay in KO mice, revealed no direct evidence of S. neurona infection. However, there were lesions compatible with S. neurona infection in horses. The results of this investigation suggest that stress can play a role in the pathogenesis of EPM. There is also evidence to suggest that horses in nature may clear the organism routinely, which may explain the relatively high number of normal horses with CSF antibodies to S. neurona compared to the prevalence of EPM.

2. Serum antibodies to West Nile virus in naturally exposed and vaccinated horses Louis A. Magnarelli1, Sandra L. Bushmich2, John F. Anderson1, Michel Ledizet3 and Raymond A. Koski3 J Med Microbiol 57 (2008), 1087-1093

1 Connecticut Agricultural Experiment Station, New Haven, CT 06504, USA 2 Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT 06269, USA 3 L2 Diagnostics, 300 George Street, New Haven, CT 06511, USA

A polyvalent ELISA and plaque reduction neutralization tests (PRNTs) were used to measure serum antibodies to West Nile virus (WNV) in horses naturally exposed to or vaccinated against this flavivirus in Connecticut and New York State, USA. Relying on a PRNT as a ‘gold standard’, the main objective was to validate a modified ELISA containing a recombinant WNV envelope protein antigen. It was also important to assess specificity by testing sera from horses that had other, undiagnosed illnesses. Sera for the latter study were obtained from 43 privately owned horses during 1995–1996. Analyses by an ELISA and a PRNT confirmed the presence of WNV antibodies in 21 (91 %) of 23 sera from naturally exposed horses and in 85 % of the 20 vaccinated subjects; overall results for both study groups were highly concordant (91 % agreement). Humoral responses of naturally exposed and immunized horses were similar. Both serological tests were useful in confirming past infections with WNV, but there was no evidence that horses with undiagnosed illnesses were exposed to WNV prior to a 1999 outbreak in Connecticut, USA.

3. Exercise alters the immune response to equine influenza virus and increases susceptibility to infection
R. W. FOLSOM, M. A. LITTLEFIELD-CHABAUD†, D. D. FRENCH‡, S. S. POURCIAU, L. MISTRIC and D. W. HOROHOV* Equine vet. J. (2001) 33 (7) 664-669

Equine influenza virus remains a major health concern for the equine industry in spite of ongoing vaccination programmes. Previous work has shown that the immune system of horses can be affected by strenuous exercise. The possible adverse consequence of exercise-induced alterations in lymphocyte responses measured in vitro was unknown. Here we demonstrate that subjecting vaccinated ponies to a 5 day strenuous exercise program results in a significant suppression of their natural killer cell-mediated immune response to equine influenza virus as measured by decreased lymphoproliferation and gamma interferon pro duction measured in vitro. These same ponies also demonstrated increased susceptibility to influenza disease following a challenge exposure to the same strain of virus. Rested ponies that had received the same vaccine and challenge were completely protected from disease. Our results demonstrate that exercise-induced suppression of the equine immune response to influenza virus can be associated with an increased susceptibility to disease.

3. Seroprevalence of antibodies to Sarcocystis neurona in equids residing in Oklahoma
J Vet Diagn Invest 15:597–600 (2003) Bradford G. Bentz1, Katie A. Ealey, Jennifer Morrow, P. L. Claypool, Jeremiah T. Saliki

Abstract. A sampling of equids from the state of Oklahoma produced an estimate of seroprevalence of antibody to Sarcocystis neurona to be about 89.2%. (note: up to 96% in the Eastern Counties) This figure represents the highest currently reported regional seroprevalence of antibody to this organism. Regional differences in seroprevalence were found in the western
quadrants of the state relative to the eastern quadrants of the state, with a significantly higher seroprevalence in the eastern regions. Thoroughbreds were found to exhibit a statistically significant lower seroprevalence as a breed group when compared with other breeds sampled.

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Note from Shirley

Personally I find it is easier to give the content of a small capsule of high potency of the human immune modulating formula to very sick dog or cat, especially if they have difficulty eating or if they have a sensitive stomach. Finicky dogs and cats may not like the taste of the canine or feline formulas. I gave my dog Shasta the human immune formula which I think is a more potent immune booster. I started by giving her a couple of capsules of a natural immune enhancing supplement a day (I slipped a capsule in her mouth one at a time AM and PM (or mixed it in her food) for 3 consecutive days. As she did well, I increased the dosage to 3 capsules a day. A few weeks later, as she had recovered her health, I decreased the dosage to 2 capsules a day as a maintenance dosage. Shirley

The Germ Survival Guide recommends this unique immune enhancing supplement. This new book written by Kenneth A. Bock, M.D., Steven J. Bock, M.D. is designed to give families and individuals preventative strategies to use to protect against germs and environmental threats. These immune molecules are extolled in the book as an effective way to optimize immune system function so that personal immunity is at its best in the face of a variety of health threats.

Unique immune enhancing molecules for your cats, dogs, horses, cattle and any other animals are the most scientifically advanced immune support supplements ever formulated to keep all of your animals healthy and happy. Your animal's immune system functions just like yours does. It is responsible for keeping your animal healthy. There is nothing on the market that can help support their immune system like this product. It has been proven in independent studies to increase immune system function by over 430%. Whether your animals are experiencing a particular health challenge or you just want to protect them from future problems, you can now do it safely with this immune supplement.

Have a question or need assistance? Email Shirley or call 323-522-4521

Mange - Many normal dogs carry the mange parasite. Holistic veterinarians believe that it becomes a problem and spreads through the skin when there are immune problems, inherited skin defects or illness for other reasons. Holistic treatments aim to improve the general health, particularly the immune system, and to homeopathically treat the inherited factors.

Demodectic Mange Mites and Immunity

Healing animal's compromised immune systemDr. Will Falconer DVM - "... it’s a fact: we all have demodectic mites as residents on our skin. Why aren’t we all itchy and broken out with eruptions? Only one reason: the immune system keeps these parasites in check. So, when a dog is diagnosed with demodectic mange, and he’s got crusty patches around his face or toes or all over, what that means, first and foremost, is that his immune system needs help! Unfortunately, the common treatment is to dip the affected dogs in very toxic chemicals to kill the mites. So toxic, in fact, that the personnel dipping the dog wear rubber gloves andaprons! This has never made sense to me, as we know poisons have a clearly detrimental effect on the immune system.

Wouldn’t it make more sense to strengthen the immune system and thereby get the normal flora of mites back in control? It can be done, and this unique immune support substance would be the best course. To discourage mites topically, paint on lavender essential oil, diluted 1:10 with almond oil. This can be applied twice a day. Be sure to avoid the eyes, however. You’ll need to give this regimen time, from at least a few weeks to a few months. And, again, don’t short change nutrition, avoid vaccines, and work with your homeopathic veterinarian to improve health and cure the underlying illness that allowed the immune system to get so sluggish. These products have absolutely no toxicity or side effects even at mega doses. You may increase the amounts even further to achieve the desired level of immune efficiency.".

The key to self-healing is a strong defense system

Will Falconer DVM. - "Nearly everything that goes wrong with us and our pets, with the exception of trauma - i.e. broken bones, etc., can be traced directly to an immune system failure". Pollution, drug overload and nutrient-poor diets compromise our immune health. The key to self-healing is a strong defense system, which protects dogs and cats from everything from the flu germs to cancer cells. More than their mainstream counterparts, holistic veterinarians believe that a weak immune system plays a key role in causing disease. Drugs aren't the answer for immune enhancement. The immune system is not responsive to drugs for healing. Antibiotics fight infection, but they don't affect whatever weakened the immune system in the first place. This is why holistic veterinarians focus less on things that cause diseases and more on those that affect the body's defenses.

Do you have a question about holistic animal health or need assistance? Contact Shirley
Call 323-522-4521 or 323-989-3372

Shirley's Wellness Cafe

Animal Health and Wellness